3- Thiophenemalonic acid

TicarcHHn [34787-01-4] (SB) (52) is a significant penicillin antibiotic that incorporates the thiophene ring system. A number of routes to the required intermediate, 3-thiophenemalonic acid [21080-92-2] have been used over the years. Those from thiophene-based starting materials have involved 3-methylthiophene and 3-bromothiophene. 

SEN 05a] Senadeera G.K.R., Kitamura T., Wada Y. et al, Photosensitization of nanociystalline Xi02 films by a polymer with two caiboxyhe groups, poly (3-thiophenemalonic acid) , Solar Energy Materials and Solar Cells, vol. 88, pp. 315-322, 2005. 

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