2-thiophene boronic acid

Temp. (°C) Benzeneboronic acid 8.5 MHClOt H0 = -4.69 Thiophene-2-boronic acid Thiophene-3-boronic acid 6.0 M HClOx Ho 2.83... 

Suzuki coupling reactions of 16 with 4-methoxyphenylboronic acid and 2-ben zo[ h] thiophene-2-boronic acid in the presence of Pd(PPh3)4 and aqueous NaHC03 as base, in a mixture of toluene/ethanol (5 1) at 90 °C for 2 h, afforded the corresponding coupling products in high yields (Eq. (45)) [76]. 

The Suzuki reaction of j9-chlorobenzoyl chloride and thiophene-2-boronic acid was carried out under anhydrous conditions to furnish ketone 118 [81], providing an alternative synthesis of ketones. Behaving like simple aryl halides, iodothiophenes served as coupling partners with phenylboronic acid [82] and thienylboronic acid [83] to deliver biaryls 119 and 120, respectively. 

Reagent and condition (i) Thiophene-2-boronic acid, Pd(PPh3)4, THF, NaHC03/H20. (ii) NBS, CHCI3. 

Benzo[b]thiophene-2-boronic acid AmpC P-lactamase 27 107,108... 

Thieno[3,2-b]thiophenes carrying either four phenyl (75) or four 2-thienyl groups (76) were constructed using Suzuki cross-couplings of tetrabromo-TT (74) with phenyl- or thiophene-2-boronic acids [39] Scheme 18). 

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