Thiopental Aspirin

Other measures, much disputed, include the prior injection of diazepam (58,59), procaine or hdocaine (57), vitamin C, suxamethonium itself (10 mg), and aspirin (51,52). The combined use of atracurium 0.05 mg/kg and hdocaine 1.5 mg/kg reduced the incidence of postoperative myalgia to 5% compared with 75% in controls (57). Thiopental, injected immediately beforehand, is also said to have some effect, as is giving the suxamethonium slowly. 

Also analyzed aspirin, chlordiazepoxide, chlorprothixene, clonazepam, caffeine, diazepam, doxylamine, ethosuximide, furosemide, haloperidol, hydrochlorothiazide, methocarbamol, methotrimeprazine, nicotine, oxazepam, procaine, promazine, propafenone, propranolol, salicylamide, temazepam, tetracaine, thiopental, triamterene, veraptimil, zolpidem, zopiclone... 

Simultaneous acetaminophen, acetanilide, N-acetylcysteine, N-acetylprocainamide, amo-barbital, aspirin, barbital, butabarbital, butalbit, caffeine, carbamazepine, cimetidine, codeine, cyheptamide, diazoxide, diflunisal, disopyramide, ethchlorvynol, ethosuximide, gentisic acid, glutethimide, heptabarbital, hexobarbital, ibuprofen, indomethacin, keto-profen, mefenamic acid, mephenytoin, mephobarbital, methaqualone, methsuximide, methyl salicylate, methypiylon, morphine, naproxen, nirvanol, oxphenylbutazone, pentobarbital, phenacetin, phenobarbital, phensuximide, phenylbutazone, phenytoin, primidone, procainamide, salicylamide, secobarbital, sulindac, thiopental, tolmetin, trimethoprim... 

The anaesthetic dosage of thiopental is reduced, and its effects prolonged by pretreatment with aspirin or probenecid. 

A study in patients about to undergo surgery found that pretreatment with aspirin 1 g (given as intravenous lysine acetylsalicylate) one minute before induetion redueed the dosage of thiopental by 34%, from 5.3 to 3.5 mg/kg. Initially thiopental 2 mg/kg was given followed by increments of 25 mg until the eyelash reflex was abolished. The same study also found that oral probenecid 1 g given one hour before anaesthesia reduced the thiopental dosage by 23%, from 5.3 to 4.1 mg/kg. 

Not understood. It has been suggested that aspirin and probenecid increase the amount of free (and active) thiopental in the plasma since they compete for the binding sites on the plasma albumins. ... 

Information is limited but what is known shows that the effects of thiopental are increased by aspirin and probenecid. Be alert for the need to reduee the dosage. However, note also that regular aspirin use may ineiease the risk of bleeding during surgery, and it is often recommended that aspirin should not be taken in the week before surgery. ... 

---