Thiol reaction with

Figure 1.69 SAMSA is an anhydride compound containing a protected thiol. Reaction with protein amine groups yields amide bond linkages. Deprotection of the acetylated thiol produces free sulfhydryl groups for conjugation.

Figure 22.12 The reaction of SPDP with PE creates a maleimide derivative capable of coupling thiols. Reaction with a sulfhydryl-containing molecule forms a conjugate through a thioether linkage.

With nucleophiles such as alcohols (enolates) and thiols, reaction with aldehydes yields the corresponding addition products.31... 

Write equations for a thiol reaction with heavy metal ions and the production of disulfides that results when thiols are oxidized. (Section 3.9)... 

A general role for a thiol reaction with platinum complexes as deactivation cannot at present be stated, although tissue binding involving sulfhydryl groups is well documented and biochemical aspects have been discussed (Chapter 2.4). The reactions of Pt complexes with methionine... 

FIGURE 2 Protein thiol reaction with Eiiman s reagent. 

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