Thiocarboxylic, Boronic, Phosphonic, Phosphoric, and Sulfonic Acids

There have been a few reports of enzymatic cleavage of linkers for carboxylic acids from PEG-grafted polystyrene supports, such as Tentagel (Table 3.8). Some of these linkers are also sensitive towards acids or bases, and will, therefore, only remain uncleaved under a narrow range of reaction conditions. 

2 Linkers for Thiocarboxylic, Boronic, Phosphonic, Phosphoric, and Sulfonic Acids 

Sasrin-derived sulfonates have been prepared in the presence of DMAP, without significant loss of sulfonate through displacement by DMAP [201]. 

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