Thiocarbamates, elimination with

Thiocarbamates, formed by reaction of a thiol with an isocyanate, are stable in acidic and neutral solutions and are readily cleaved by basic hydrolysis. The 3-elimination... 

Microwave-assisted reaction of 1-benzoyl-3-benzylthiourea and benzoyl-ethyl-thiocarbamate with benzylamine in dry media conditions using KF-Al Oj provides 1-benzoyl-3-benzylguanidine and 1-benzoyl-3-benzyl-O-ethylisourea in good yields (68 and 76%, respectively) (Marquez et al., 2006). Strong nucleophilic ben-zylamines promoted the elimination of sulfur as H S by attack on the thiocarbonyl group in both thiourea and thiocarbamates to afford guanidines and isourea, respectively. Very important nonpurely thermal MW specific effects were found responsible for stabilization by coulombic interactions between materials and waves. 

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