Thieno pyrrole

Dichloromaleimide is converted at or below ambient temperature to a thieno-pyrrole by malononitrile-methoxide, and then hydrogen sulphide [3378]. Several dithienothiophenes are synthesized by oxidative cyclization of the lith-iated intermediates, but when the latter are unstable, the dibromosulphides may be treated with butyllithium and copper(II) chloride [2287]. The chlorodibromo-quinoline (81.2) is efficiently converted into the fused thiophene when heated with thiourea in a protic solvent [2873]. 

Chu et al reported a new alternating copolymer of dithienosilole and thieno-pyrrole-4,6-dione (P3), which was synthesized by Stille coupling of a ditin compound and dibromo compound in refluxing toluene/dimethylformamide (10 1) with Pd(PPh3)4 as the catalyst. The purified pofymer has a of 28 kDa and a PDI of 1.6, as determined by GPC using chlorobenzene (CB) as the eluent. P3... 

UV, 6, 1032 (74JA4268) 47/-Thieno[3,4-c]pyrrol-5-ium-4-ide, 5-methyl-UV, 6, 1032 (74JA4268) 47/-Thieno[3,4-c]pyiTol-5-ium-4-ide, 5-phenyl-UV, 6, 1032 (74JA1817) l-(2-Thienyl)ethyl acetate kinetic data, 4, 952 (77AHC(21)119>... 

Thieno[2,3-d ]pyrimidin-4(3 H) -one, 3-methyl-synthesis, 4, 1017 Thieno[2,3-d ]pyrimidin-4-ones synthesis, 4, 1017, 1018, 1022 Thieno[2,3-6]pyrrole, 5-aryl-synthesis, 6, 1009 Thieno[2,3-6]pyrrole, N-benzyl- H NMR, 4, 1042 UV spectra, 4, 1044 Thieno[2,3-c]pyrrole, N-ethyl-UV spectra, 4, 1044 Thieno[3,2-6]pyrrole, 5-aryl-synthesis, 6, 1009 Thieno[3,2-6]pyrrole, N-benzyl- H NMR, 4, 1041, 1042 lithiation, 4, 1051 UV spectra, 4, 1044 Thieno[3,2-6]pyrrole, 2,3-dihydro-desulfurization, 6, 984 oxidation, 6, 981... 

Thieno[3,2-6]pyrrole, 5-ethoxycarbonyl-acylation, 4, 1050 synthesis, 4, 1070 Thieno[3,4-c]pyrrole, 5,6-dihydro-synthesis, 6, 987... 

Thieno[3,2-6]pyrrole-2-carboxylic acid, 5-aryI-synthesis, 4, 819... 

UV spectra, 4, 1044 Thieno[3,4-6]pyrroles reduction, 4, 1074 Thienop, 4- c]py rroles addition reactions, 4, 1060 dipole moment, 4, 1040 mass spectra, 4, 1045 oxidation, 4, 1063 reduction, 4, 1063... 

Thieno[3,2-6]pyrroles (58) reacted with bromine at both the pyrrole fi-position and the thiophene a-position with comparable ease. No monosub-... 

Pyrrolo[l,2-fl]thieno[2,3-c]pyrazine (186) brominated mainly in the fused pyrrole ring. Only the third bromine atom introduced substituted the thiophene /3-position (86JHC17). 

PHC431, 2005PHC389) discussions. The specialized review (1993H601) surveyed the synthesis of 1,5-benzodiazepines with three-, four- and five-membered rings fused to different positions of the 1,5-benzodiazepine skeleton. Synthesis of DNA-interactive pyrrole[2,l-c][l,4]benzodiazepines (1994CR433) and medicinal chemistry aspects of the novel thieno benzodiazepine antipsychotic Olanzapine (1997MI1743) have been reviewed. 

Dihydrothiophene- and 2,5-dihydrothiophene-l,l-dioxide-bridged 142 and 143 are based on thieno[3,2-b]pyrrole (02OL3879, 03ZOR1725) (Scheme 45). 

A new class of photochromic diarylethenes containing thieno[3,2-b] thiophenes, dithieno[3,2-b 2, 3 -d]thiophene (08CC5203), and dithieno [3,2-fc 2, 3 -d]pyrroles (09CEJ10005) with photoswitchable luminescence properties were synthesized by Suzuki cross-coupling reactions (Scheme 48). 

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