Thieno pyridines biological activities

Thieno[2,3-c]pyridine, 2-amino-6-benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydro-biological activity, 4, 1015 Thieno[2,3-c]pyridine, 4,5,6,7-tetrahydro-biological activity, 4, 1015 Thieno[3,2-6]pyridine, 3-hydroxy-synthesis, 4, 1010... 

USP6433167). Earlier data on the biological activities of thieno[2,3-c]pyridines and related structures were summarized in review (1987KFZ536). 

Thieno[2,3-c]pyridine derivatives are often prepared according to methods based on the Pictet-Spengler reaction. For example, thiotryptophane esters and amides 209 undergo cyclocondensation with formaldehyde to give biologically active benzothienopyridines 191 (as tosylates or hydrochlorides) (1989JAP63-96188,... 

Data on the biological actions of dipyridothiophenes are scarce. Information is lacking in the review (1987KFZ536), where considerable attention was given to the pharmacological aspect of the use of thienopyridine derivatives. The anticonvulsive activity of substituted pyrido[3,2, 4,5]thieno[3,2-6]pyridine, which has low toxicity, was documented (1996RFP1417446). 

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