2-Thiazolyl hydrazine

TABLE 11-22- l-AROYL-2-(2-THIAZOLYL) HYDRAZINES FROM AROYLTHIOSEMICARB AZIDES"... 

The exclusive acid-catalyzed transformations of hydrazobenzene 29 into 4,4 -diaminodiphenyl 30, A-phenyl-A -(2-thiazolyl)hydrazine 31 into 2-amino-5-... 

V-Phenyl-A/ -(2-thiazolyl)hydrazine (1) and iV,A -bis(2-thiazolyl)hydrazine (3) also undergo acid-catalyzed benzidine-type rearrangement into 2-amino-5-(p-aminophenyl)thiazole (2) and 5,5 -bis(2-aminothiazole) (4), respectively (Scheme 3.28). 

N,N-Diphenyl-N -(4-phenyl-2-thiazolyl) hydrazine refluxed briefly with p-nitroso-dimethylaniline in glacial acetic acid-ethanol (1 1) 4-phenyl-5-(p-dimethyl-aminophenylimino)-2-thiazolone diphenylhydrazone. Y 94%. F. e. s. H. Beyer, W. Schindler, and K. Leverenz, B. 91, 2438 (1958). 

Trichomoniasis - Oral metronidazole (x) continues to be the drug of choice in the treatment of trichomoniasis.59 Some 1,2-diacyl-his (5-nitro-2-thiazolyl) hydrazines (XIV) were found to be active m vitro against... 

Ethyl-N-(2 thiazolyl)carbainate reacts with aqueous hydrazine to give 271 (Scheme 165) (263). 

N-(2-Thiazolyl)cyanamide may be converted into guanidino derivatives by the action of hydrazines (487). /V-Aryl-N -(4-aryl-2-thiazolybguanidines... 

Thiazolyl)pyrimido[4,5-i/]pyridazines have been prepared by utilizing the reaction of the active methylene compound 46 with benzenediazonium chloride (Scheme 24) to give a hydrazone, which cyclizes spontaneously <1999JPR147>. A further approach described recently <2002HAC108> involves reaction of the malononitrile derivative 47 with a further equivalent of malononitrile, forming a pyrimidine with a suitably disposed hydrazine, which cyclizes on exposure to strong base (Scheme 25). 

A soln. of 4-phenyl-1,2-dithiolium bromide and 2-hydrazinobenzothiazole in pyridine warmed 1 hr. on a steam bath, and refluxed 1 hr. ->-crude l-(2-benzo-thiazolyl) -4-phenylpyrazole. Y ca. 100%. F. e , also with 85%-hydrazine hydrate without pyridine, s. E. Klingsberg, Am. Soc. 83, 2934 (1961). 

C3 H26N3S]- 2-Phenyl-2-(4-phenyl-2-thiazolyl)-1 -(triphenylmethyl)hydrazy 1 Nr. 83 Oxidation of the corresp. hydrazine with Pb02/ Benzene EPR/ 300... 

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