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Thiazolo thiazolium

Carbene structure, of thiazolium salts in basic medium, 31.34 Carbocation, in thiazolium salts, 32 Carbocyanines. see Trimethine thiazolo-cyanines... [Pg.148]

The thiazole-2-thione (51) with an a-halo ketone gives the intermediate (52) which is cyclized by strong acid into the thiazolo[2,3-/ thiazolium salt (53) (77HC(30-i)l). A wide variety of [5,5]-fused systems are prepared in this way. [Pg.672]

Many syntheses of imidazo-fused systems involve cyclization of amino-substituted heterocycles (or their tautomers), suitably substituted at an adjacent ring position. This provides a convenient route to imidazo[2,l-A]thiazoles, imidazo [l,2- ]imidazoles (Scheme 22), imidazo[l,2-A]pyrazoles, imidazo[l,5- ]imidazoles, and imidazo[l,5-c]thiazoles. Similarly, the thiazolium salt 33 easily undergoes the cyclization resulting in thiazolo[3,2-Mbenzimidazoles 34 after a subsequent basic treatment (Scheme 23) <2005MOL327, CHEC-III(11.04.9.1.1)152>. [Pg.895]

The usual precursor to the thiazolo-fused systems is a cyclic thioamide or its tautomeric form . A convenient approach to the synthesis of bicyclic [5-5] systems, e.g., the tricyclic thiazolium salt 46 and 2,3-dihydroimidazo[2,l-A]thiazol-5-one 48, involves the N,S-dialkylation of appropriate precursors 45 and 47 with 1,2-dihaloalkanes (Scheme 31) <1999JMC2828, 2002EJC777>. [Pg.897]

Abweichend von den o.g. Reaktionen der l,3-Thiazolium-3-methide mit Alkenen bilden sich mit Alkinen 1,3-Thiazolo-azepine als 1 2-Cycloaddukte985. [Pg.354]

Cyan-2-methyl-6-phenyl- 233 < 1,3-Thiazolo[2,3-b]-l,3-thiazolium)-3-olat 321... [Pg.1182]

The thiazolo[2,3-6]oxazole (104) has also been prepared by a base-catalyzed type A cyclization <85CC454>. In this case, the cyclization of thiazolium salt (102) is believed to occur by intramolecular nucleophilic attack of a hydrate dianion intermediate (103) on the positively charged ring. However, other workers have cast doubt on the structure of the product from this reaction claiming, on the basis of x-ray analysis, that it exists as (105) in the solid phase <85CC1113>. [Pg.109]

Nucleophilic Substitution. Several nucleophilic replacements in benzo-thiazolium salts (82) and (83) have been reported. The reactions (see Scheme 4) were studied chiefly for the purpose of comparison with those of the analogous thiazolo[2,3-Z ]benzothiazoles (see p. 702). The results agree with the general experience that quaternization of benzothiazole enhances its susceptibility towards nucleophilic reagents. ... [Pg.671]

Thiazolo[3, 4 -l,2]pyrazino[7,8-a]benzimidazoles.—[C3NS-C3N2-C4Ng-C6]. In connection with their more detailed work on thiazolodiazepino-benzimidazoles (see p. 714), Maynard et al. have condensed 2-(4 -thiazolyl)benzimidazole and 1,2-dibromoethane to produce 5,6-dihydro-thiazolio[3, 4 -l,2]pyrazino[7,8- ]benzimidazole bromide, and described several of its reactions, notably the cleaving of its thiazolium ring. ... [Pg.712]

Thiazolo[3, 4 >l,2][l,4]diazepino[8,9-a]benzimidazoles. — [CgNS-CaNz-C -CrN2], l-(3 -Bromopropyl)-2-(4"-thiazolyl)benzimidazole (339) isomerizes above 100 °C to 6,7-dihydro-5/f-thiazolio[3, 4 -l,2][l,4]diazepino[8,9-a]-benzimidazole bromide (340), the structure of which is established by its spectral properties and chemical behaviour. Treatment with alkali cleaves its thiazolium ring the resulting thiol (341 R = SH) is isolable as the 5 >methyl derivative (341 R = SMe) and is oxidized by hydrogen peroxide... [Pg.714]

Meso-lonlc Thiazolo[2,3-6]thiazoles.—Thiazoline-2-thione (179) reacts readily with 2-bromo-2-phenyIacetyl chloride in the presence of base (Scheme 16) to produce 2-phenylthiazolo[2,3-6]thiazolium-3-olate (180), which undergoes cycloaddition reactions with acetylenic and olefinic dipolarophiles in much the same way as (175). With dimethyl acetylenedicarboxylate, for example, the thiazolo(3,2-a]pyridin-5-one (181) is formed. ... [Pg.299]


See other pages where Thiazolo thiazolium is mentioned: [Pg.876]    [Pg.878]    [Pg.878]    [Pg.152]    [Pg.876]    [Pg.878]    [Pg.878]    [Pg.992]    [Pg.876]    [Pg.878]    [Pg.878]    [Pg.283]    [Pg.992]    [Pg.186]    [Pg.878]    [Pg.878]    [Pg.141]    [Pg.252]    [Pg.258]    [Pg.327]    [Pg.710]    [Pg.159]    [Pg.276]    [Pg.258]    [Pg.282]    [Pg.282]    [Pg.291]   
See also in sourсe #XX -- [ Pg.672 ]




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