Thiazolidinone ring structure

This sponge, found in the Red Sea, produces a number of toxins, three of which have been isolated and identified as possessing a thiazolidinone ring that is connected to a fourteen-membered macrolide ring.47 Latrunculins A and B have been assigned structures (42) and (43), and latrunculin C is a stereoisomer of (42). 

Several triazine ring opened derivatives were screened, among which the trans configured derivatives 6 and, especially, the thiazolidinone 7 showed very interesting activities against T. urticae and served as a lead for a broad chemical optimization program. Table 26.2.6 shows selected structure-activity data [17]. 

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