Thiazole and 1,3-Selenazole C-Nucleosides

Because of the close similarities of their methods of preparation and their properties, these two categories of C-nucleosides are reviewed together. 

Cyclocondensation of the bicyclic 2,5-anhydro-D-allose derivative 312 with 2-(methylamino)thioethanol gave the 2-)8-D-ribofuranosylthiazolidine 

Many 2-thiazolyl C-nucleosides (565) were prepared by the Hantzsch reaction of the )8-D-ribofuranosylthioamide 563 with a-haloketones (75MI8 77JMC256 82MI16 83MIP1). 4-Carboxamido-2-/l-D-ribofuranosylthiazole 

Since then, articles have described the preparation of tiazofurin 566 from 

An interesting synthesis of tiazofurin is that in which the penicillinate derivative 573 was condensed with the 2,5-anhydro-D-allonoyl chloride 507 

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