Thiazide-like diuretics chlorthalidone

Chlorthalidone (49) is another thiazide-like diuretic agent that formally contains an isoindole ring. Transformation of the amine in benzophenone, 47, to a sulfonamide group by essentially the same process as was outlined for chlorexolone (46) affords Intermediate 43. This product cyclizes to the desired pseudoacid 1-ketoisoindole (49) on successive treatments with thionyl... 

Mist of the thiazide and thiazide-like diuretics are aKsorbed dl alter oral administration, except ehlumthiazide (only. vt 10% of which is absorbed). Their on.sct of action sially occurs within I to 2 hours, and their peak diuretic. iket is expressed within. 1 to 6 hours. " Most diuretics in i ll class are bound extensively to plasma proteins (or to tdl ItsKicell CA for chlorthalidone and metolazone - ). 

In addition to the thiazide diuretics like hydrochlorothiazide (19) and chlorthalidone used in the treatment of hypertension for a long time, a few newer diuretics such as azosemide and torasemid (188) have been introduced for... 

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