Thiating agents

The Willgerodt reaction allows amide synthesis from aromatic aldehydes or ketones, using a secondary amine and a thiating agent. The mechanism of the more convenient Kindler modification, employing sulfur and morpholine, has been reviewed.281... 

The Willgerodt Reaction allows the synthesis of amides from aryl ketones under the influence of a secondary amine and a thiating agent. The mechanism involves the formation of an enamine which undergoes thiation, and the carbonyl group migrates to the end of the chain via a cascade of thio-substituted iminium-aziridinium rearrangements. 

Dehydrodeoxynupharidine (42) reacts with electrophilic thiating agents, such as ArSX, resulting in a separable mixture (1 1) of two diastereomeric adducts 43 and 44 (47). The reaction of 42 with p-toluenesulfonyl chloride was studied in detail (48) and products 45-49 identified. The configuration at C-7 was determined by circular dichroism (48). 

Lawesson s reagent [2,4-bis(4-methoxyphenyl)-l, 3,2,4-dithiadiphosphetan 2,4-disulphide] has been employed as a thiating agent it also acts as an amino-... 

LMW heparin, enoxaparin, for preventing VTE after major orthopedic surgery (30). The results from a meta-analysis show thiat fondaparinux (10) is associated with an overall risk reduction versus enoxaparin for the prevention of venous thromboembolism. Of aiU the LMW heparins, enoxaparin is widely regarded as the treatment standard for VTE prophylaxis. Fondaparinux (10) is an injectable solution for the prevention of DVT and is the only antithrombotic agent approved in the United States for hip fracture surgery. 

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