Thiamin trisphosphate

The cofactor form of thiamin is thiamiri pyrophosphate (TPP). TPPis released from dietary proteins during hydrolysis in the gastrointestinal tract and then hydroly 2ed to thiamin- The thiamin is absorbed and transported into various tissues, where it Is converted back to TPP by the action of thiaminokinase (Figure 9.70). A small proportion of the body s thiamin occurs as thiamin monophosphate (TMP) and thiamin trisphosphate (TTP). 

Thiamin trisphosphate accounts for a small proportion of the thiamin in the brain. The function of this compound is not clear, nor is it known if it plays a part in the neurological signs that occur with thiamin deficiency. Recent studies have shown that exposure of baboons to a flickering light can induce changes in brain levels of thiamin triphosphate. Flickering lights are often used in the study of convulsions, The work available on the compound is not extensive. 

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