Thia-7-aza-twistanes Pathway

2-Thia-7-aza-twistanes (correct name) or 2-Aza-7-thia-twistanes, Resp. Pathway 0 (G 30 G 33) 

Studies on intramolecular cyclizations using pathway 0 were mainly carried out with the bicyclic endo-2-amine 231 having an exo-bromine atom at C(6) as leaving group. 

Best results have been obtained in 1,2-dichloroethane at 80° in the presence of solid Na2C02, where the 10 -bromo-2-aza-7-thia-twistane 234 was formed in 97% yield. Analogous cyclizations were carried out with 232 (- 235), 233 (- 236) and 237 - 238). 

---