Thermosensitive Composite Gel

A thermosensitive composite gel for use as a bone graft substitute has been designed (19). The gel can provide a more suitable microenvironment by using an amphiphilic triblock copol5uner consisting of methoxy poly (ethylene glycol), and poly(lactic-co-glycolic acid). 

By aqueous dispersion of the triblock copol5uner mixed with different ratios of hydroxyapatite/tricalcium phosphate, a composite gel imderwent a sol-gel-sol transition when the temperature was increased from 4°C to 70°C. The particle size and critical micellization concentration were increased by adding the ceramic materials. 

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