Thermoregulation hyperthermia

When cocaine is repeatedly administered, DAergic receptor numbers are altered.4041 The likelihood of hyperthermia may be increased with chronic cocaine abuse if the DAergic receptors involved in thermoregulation are undergoing adaptive changes with chronic cocaine exposure. In keeping with this hypothesis, cocaine delirium victims had a different profile of D2 receptor binding... 

Thermoregulation 5-HTia agonists cause hypothermia in experimental animals S-HTjg and 5-HT2 agonists cause hyperthermia in experimental animals... 

Britt, BA (1991) Malignant Hyperthermia - A Review Thermoregulation Pathology, Pharmacology and Therapy (Schonbaum, E and Lomax, P eds) Pergamon Press, New York, USA, pp 179-292. 

Thermoregulation Note DA = dopaminergic. p may mediate hypothermia 8 may mediate hyperthermia Hypothalamus... 

Associated with increased physical activity and altered thermoregulation, ecstasy has been reported to cause unconsciousness, seizures, hyperthermia, tachycardia, hypotension, disseminated intravascular coagulation, and acute renal insufficiency, as well as death. 

Rick There is. I believe, a species-specific effect in hypothermia and hyperthermia. This has been shown by Feldberg and Myers (1964) and others in their work with catecholamines. To what extent is this species-specific effect on thermoregulation present with anticholinesterases ... 

An elevated body temperature due to failed thermoregulation. It is usually defined as a temperature greater than 37.5°C to 38.3°C (100°F to 101°F). Hyperthermia occurs when the body produces or absorbs more heat than it can dissipate. When the elevated body temperatures are sufficiently high, hyperthermia is a medical emergency and reqnires immediate treatment to prevent disability and death. See also Heat Exhaustion (Heat Collapse Heat Prostration Heat Stress). 

---