Thermodynamic anchor points

With the smaller cyclic peptides the lack of flexibility combined with the lack of an amino anchor point means that deprotonation of the peptide groups requires more strongly alkaline conditions than for their linear counterparts. However, once formed the cyclic complexes can be thermodynamically and kinetically more stable.97 This also applies to Cu in oxidation state III. 

For most sterically stabilized dispersions whose particles are fully-coated by well-anchored high polymeric stabili ng moieties, the practical thermodynamic limit to stability is the 0-point for the stabilizing moieties in free solution. 

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