Therapy-related acute promyelocytic

Mays AN, Osheroff N, Xiao Y, Wiemels JL, FeUx CA, Byl JA, et al. Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15 17) therapy-related acute promyelocytic leukemia. Blood 2010 115(2) 326-30. 

Zompi S, Legrand O, Bouscaiy D, Blanc CM, Picard F, CasadevaU N, Dreyfus F, Marie JP, Viguie F. Therapy-related acute myeloid leukaemia after successful therapy for acute promyelocytic leukaemia with t(15 17) a report of two cases and a review of the literature. Br J Haematol 2000 110(3) 610-13. 

Two patients with acute promyelocytic leukemia developed therapy-related myelodysplasia 2.0-2.5 years after complete remission and then acute myeloid leukemia both had received anthracyclines (39). In both cases the cytogenetic changes that usually occur after the use of alkylating agents were observed. There has only been one previous similar report after successful therapy with anthracyclines, but these observations suggest that anthracyclines can cause acute myeloid leukemia similar to that caused by alkylating agents. 

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