Therapeutic drugs emesis

Finally, the ability of aprepitant to block emesis, a therapeutically relevant endpoint for the ultimate clinical application of the drug, as discussed below, was tested in the presence of several emetogens in the ferret. This species is believed to be a valid animal model for cancer chemotherapy-induced emesis in humans. Aprepitant (1) effectively blocked retching and vomiting due to cisplatin, apomorphine, and morphine at a dose of 3.0 mg/kg p.o. and 0.3 mg/kg i.v. (in the case of cisplatin).8... 

As for agonists, compounds selective for the the various subt5q)es are investigated as potential antiparkinsonian drugs. For instance, Dj agonists could be preferable, since they should not induce nausea and emesis. Still, in order to really ascertain the therapeutic value of... 

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