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Therapeutic Anti-HER2 Antibodies

A major development in the treatment of breast cancer has been the success of Herceptin, an anti-HER2 monoclonal antibody, in treating the 20-25% of breast cancers in which HER2 is overexpressed (Slamon et al, 2001). Although not a cure—average life expectancy is extended [Pg.18]

Gerstner, R. B., Carter, P., and Lowman, H. B. (2002). Sequence plasticity in the antigen-binding site of a therapeutic anti-HER2 antibody./. Mol. Biol. 321, 851-862. [Pg.24]

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