Theoretically Based Carbocupration Reaction Pathway

The carbocupration of acetylene has been studied systematically for five model species - MeCu, Me2Cu, Me2CuLi, Me2CuLi LiCl, and (Me2CuLi)2 [91] - all of which have been invoked once in a while in discussions of cuprate mechanisms. A few general conclusions have been made regarding the reactivities of these reagents with 71-acceptors  

12) Hiis four-cenlered patliway requires a large aniounl of energy, since tli valenl Me Cu bond 155 kcal mol [93]) niusl be deaved. A neulral RCu spe ctes is therefore nol a reactive nudeopbtle. 

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