Theonellin isocyanide

Reviews of the syntheses of marine natural products, including marine isonitriles, have appeared recently [72]. After the early synthetic challenges of the tricyclic 9-isocyanopupukeanane (76) [73, 74] and 2-isocyanopupukeanane (78) [75] were met in 1979, additional syntheses of marine isonitriles were reported during 1986-1991. These were ( )-7,20-diisocyanoadociane (95) [63], ( )-axisonitrile-1 (1) and ( )-axamide-l (3) [76], the axisonitrile-4 triad (7-9) [78], and ( )-8,15-diisocyano-ll(20)-amphilectene (96) [79], and theonellin isocyanide (85) [80],... 

Using the triflic anhydride method, the biomimetic theonellin isocyanide has been synthesized from its formamide in 89% yield [1238]. Theonellin is a marine sesquiterpene. 

Ichikawa, Y. (1991) First synthesis of theonellin isocyanide. Synlett,... 

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