The Use of Fast-LC-MS in Combinatorial Chemistry

Combinatorial chemistry has become of increasing importance, particularly within drug companies, in allowing the very rapid synthesis of large numbers of candidate molecules which require characterization and testing for their effectiveness. An important part of the characterization of any molecule is the determination of its molecular weight and LC-MS has been used extensively for this purpose. With 

High Performance Liquid Chromatography-Mass Spectrometry 

When low -molecular-weight compounds are involved, both APCI and electrospray ionization are potentially of value and the first task is to decide which of these will give the more useful data. 

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