The Unusual Suspects -Avrainvillamide

These studies, combined with observations that cells treated with avrainvillamide underwent increased p53 expression and that cells silenced with siRNA against nucleophosmin increased sensitivity to avrainvillamide, provided strong evidence that this event was indeed relevant to the cellular response and downstream entry into apoptosis. 

While an abundant nucleolar protein, this was the first study to identify a small molecule ligand to nucleophosmin. But although binding has been identified, the role in which dimerisation of avrainvillamide (to stephacidins) 

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