The Specificity Problem in Drug Design

Fernandez, Transformative Concepts for Drug Design Target Wrapping, DOI 10.1007/978-3-642-11792-3 7, Springer-Verlag Berlin Heidelberg 2010 

7 Wrapping as a Selectivity Filter for Molecular Targeted Therapy 

Contrasting with this troublesome aspect, the lack of conservation of the wrapping (dehydron) pattern across kinases has paramount potential to promote drug specificity, as illustrated in Fig. 7.1c, d. Thus, the structural alignment of the focal adhesion kinase (FAK, PDB.2J0L) and the insulin receptor kinase (PDB.1GAG) 

Focal adhesion kinase Insulin receptor kinase 

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