The Rho signaling

Transcviptian factors Kinases Adapter proteins Other proteins Inhibition 

Increased JNKs activation in response to ischemia and reperfusion is observed in an adult rabbit cardiomyocytes model of simulated ischemia and reoxygenation. Attenuation of JNKs activity by transfection with a dominant negative mutant of the upstream activator of JNKs, JNK kinase-2 or JNK interacting protein-1, JIP-1, reduced cell death.151 Furthermore, ischemia and reperfusion induced JNKs activation was decreased in perfused hearts subjected to ischemic preconditioning or heat stress treatment.152 

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