The Neuronal Function of Thiamin Triphosphate

Eeu ly studies showed that the development of neurologiccd abnormalities in thitimin deficiency did not follow the seune time course cis the impediment of pyi uvate emd 2-oxoglutEU ate dehydrogeneise or transketolase activities. The brtdn regions in which metabolic disturbances ene most marked were not those that are vulnerable to anatomiced lesions. These studies suggested a function for thitimin in the nervous system other them its coenzyme role. 

Thieimin triphosphate is formed in hredn emd skeletal muscle hy phosphorylation of thicimin diphosphate (Section 6.2), emd its concentration is very precisely controlled, because there is edso em active thitimin triphosphatase (Lakaye et al., 2002). In neiwous tissue thiamin triphosphate is localized 

Early studies showed that thiamin triphosphate had a role in electrical conduction in nerve cells more recent studies have shown that it activates a chloride channel in the nerve membrane, acting as a phosphate donor fBettendorff 

---