The Kupffer Cell KC

Kupffer cells are the largest reservoir of fixed-tissue macrophages and are quantitatively the most important cell type for the removal of circulating microorganisms, EPS, tumour cells. 

4 Cell Specific Delivery of Anti-Inflammatory Drugs to Hepatic Cells 

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Our work on -NO in the liver stems from an interest in the mechanism leading to the altered liver function in sepsis. We hypothesized that in the liver in sepsis, the Kupffer cells (KC) are the cells sensitive to circulating septic stimuli such as bacteria and their products [i.e., endotoxin or lipopolysaccharide (LPS)],... 

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