The Interaction of Taxol with Tubulin

The synthesis of labeled analogs of taxol has been an important aspect of research on the drug. Radioactively labeled analogs are needed for metabolism and related studies, while photoaffinity-labeled and fluorescently labeled analogues have been used to study the interaction of taxol with tubulin. This section will focus on the synthetic aspects of this work the biochemical studies of the taxol-tubulin interaction will be discussed in a later section. 

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