The determination of sodium in plasma

Sodium is determined in plasma following a two hundred and fifty-fold dilution with distilled water. 

These features are very similar to those of acrodermatitis enteropathica 

Care should be taken in automatically attributing low plasma-zinc values to zinc deficiency. As with calcium a major proportion of plasma zinc is attached to albumin and a reduction in plasma albumin will cause a reduction in total zinc values. In chronic diseases total zinc and albumin show a close relationship [44] and it is perhaps for these reasons that so many diseases are found to be associated with a reduced total plasma zinc. At present it is not clear which is the most important fraction of plasma zinc and consequently it is not justifiable to make any correction for protein alteration as has been suggested for calcium. 

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