The design of combinatorial syntheses

The reactions used when designing a combinatorial sequence should ideally satisfy the following criteria  

the reactions should be specific, relatively easy to carry out and give a high yield  

the reactions used in the sequence should allow for the formation of as wide a range of structures for the final products as possible, including all the possible stereoisomers  

the building blocks should be as diverse as possible so that the range of final products includes structures that utilize all the types of bonding to bind to or react with the target and 

it must be possible to accurately determine the structures of the final products. 

---