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The Chemical Genetics Approach

Identification of a Synthetic ABA-Agonist Using a Chemicai Genetics Screen [Pg.268]

In contrast to the classical genetic approach, a chemical genetic approach uses small molecules to directly modulate protein functions, thereby causing [Pg.268]

Redundant gene family Single gene mutation Redundant gene family Small molecule antagonist [Pg.269]

The Chemical Genetic Approach The Interrogation of Biological Mechanisms with Small Molecule Probes... [Pg.1]

The chemical genetic approach allowed the interplay between proteins (ShhN, Patched and Smoothened) to be studied using a pair of small molecule tools (robotnikinin and purmorphamine). The study complemented previous work which demonstrated that cyclopamine - a natural product that antagonises Smoothened - could reverse the effects of mutations in Patched. In both cases, the effects of modulating Patched - either indirectly, by targeting ShhN with Robotnikinin, or by mutation - could be reversed by antagonising Smoothened. [Pg.27]

See other pages where The Chemical Genetics Approach is mentioned: [Pg.77]    [Pg.58]    [Pg.174]    [Pg.285]    [Pg.291]    [Pg.292]    [Pg.293]    [Pg.174]    [Pg.232]    [Pg.260]    [Pg.268]    [Pg.269]    [Pg.271]    [Pg.282]    [Pg.1]    [Pg.2]    [Pg.2]    [Pg.3]    [Pg.5]    [Pg.7]    [Pg.9]    [Pg.11]    [Pg.13]    [Pg.15]    [Pg.17]    [Pg.18]    [Pg.18]    [Pg.19]    [Pg.21]    [Pg.23]    [Pg.25]    [Pg.27]    [Pg.27]    [Pg.28]    [Pg.28]    [Pg.29]    [Pg.31]    [Pg.273]    [Pg.456]    [Pg.23]   


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Chemical approaches

Chemical genetics

Chemical-genetic approaches

Genetic approaches

Genetic chemicals

The chemical approach

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