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The Challenge — Molecularly Targeted Therapies and New Paradigms for Clinical Trials

THE CHALLENGE — MOLECULARLY TARGETED THERAPIES AND NEW PARADIGMS FOR CLINICAL TRIALS [Pg.459]

Teicher BA. Molecular cancer therapeutics Will the promise be fulfilled In Prendergast GC, editor. Molecular cancer therapeutics Strategies for drug discovery and development. Hoboken, NJ John Wiley Sons, Inc. 2004. p. 8-40. [Pg.460]

Feldman RI, Wu JM, Polokoff MA et al. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem 2005 280 19867-74. [Pg.460]

Geney R, Sun L, Pera P et al. Use of the tubulin bound paclitaxel conformation for structure-based rational drug design. Chem Biol 2005 12 339-48. [Pg.460]

Glen RC, Allen SC. Ligand-protein docking Cancer research at the interface between biology and chemistry. Curr Med Chem 2003 10 763-7. [Pg.460]




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Clinical trials challenge paradigms

Molecular target therapy

Molecular targeted therapy

Molecular targets

Molecular therapy

New molecular

New paradigms

The Therapies

The target

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