The Catalytic Myers-Saito Cyclization

The photochemical-induced Bergman cyclization is of speci2il interest in medicine because of the ability to activate a drug molecule via localized irradiation of a tumor. 

In contrast to the Bergman cyclization, the Myers-Saito cyclization shows a much lower activation temperature, but follows a similar mechanistic pathway. 

Neocarzinostatin is a bacterial antibiotic exhibiting antitumor activity it exerts its activity through the cleavage of DNA, and this is achieved via the generation of a biradic2il intermediate via the Myers-Saito cyclization [112]. 

Our analysis of the literature showed that very few Myers-Saito cyclizations have been reported to date. 

to-land or conclude this final chapter, it would suffice to say that the synthetic methods described in this chapter diverge somewhat from those of the other chapters, in that the essence of the methods described in this chapter is the construction of the aromatic unit from scratch using elegant cycloaddition chemistries. The attractiveness of these methods stems from their atom economical nature. In fact, this approach - particularly by using completely intermolecular methods when available - leads to very high diversity because of the formation of multiple bonds in a single process. 

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