The calibration strategy space

In any chemometrics application, there are two critical attributes of calibration data that are desired  

Of course, the ultimate goal is to geuerate calibratiou data that is both highly accurate and highly relevant. However, in PAT this can be a rather difficult goal, as it seems that one often trades off accuracy for relevance, and vice versa. For example, consider two of the most common calibration strategies in PAT  

Use of on-line spectra collected on the field analyzer, with reference values obtained from lab analyses of extracted process samples, and 

Use of laboratory-synthesized calibration standards, analyzed on a laboratory version of the field 

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Figure 12.30 Illustration of the calibration strategy space, where any calibration strategy can be mapped by its relevance (x-axis) and it accuracy (y-axis). In this figure, several calibration strategies are mapped onto this...

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