The Advantages of DNA-encoded Library

Albeit on a miniaturized scale, the DNA-encoded libraries can reach a diversity level far beyond normal HTS libraries. For example, a library by Harbury s DNA routing approach has 100 million compounds Nuevolution announced on their website that their Chemetics library passed the 1 billion compound mark while GSK s DEL-B library has more than 800 million different structures. These numbers are on a par with biopolymer libraries prepared by genetics techniques such as phage-display and mRNA display, while the largest synthetic combinatorial library is around merely 2 million. Therefore, DNA-encoded library is truly an expansion of HTS into a much higher level of molecular diversity. 

Even with limited usable chemical reactions, in some cases, DNA-encoded libraries can be a unique tool to access chemical structures previously difficult 

All the molecules in a DNA-encoded library are selected simultaneously. As shown in Ensemble Discovery and GSK s data analyses, a comprehensive view of SAR can be rapidly generated from the lines and planes formed in the SAR plot, high priority structural elements can be identified and applied to the next generation of library design, or to the synthesis of discrete compounds. In addition, a clear correlation between related structural elements with binding potency strongly validates the selection itself. 

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