Tetrasaccharide-alditol

The oligosaccharide-alditols in PG-lc-4 were analyzed by GC-MS as permethylated oligosaccharide-alditols. The results indicated that PG-lc-4 contained di- to tetrasaccharide-alditols possessing glycosyl units such as Hex-(l- 4)-6-deoxyHex-ol, Pen->Pen->deoxyHex-ol, Pen- Hex->deoxyHex-ol, Hex->Hex- Hex-ol,... 

Further extension of the aforementioned trisaccharide with a NeuSAc residue a(2-6)-linked to GalNAc-ol affords the following tetrasaccharide-alditol ... 

Inhibition of the homologous SVI rabbit anti-Pn VI system showed that large amounts (30-100 mmoles) of most sugars give up to 15% inhibition, and sugar phosphates and alditol phosphates inhibit to as much as 25%, with little relation to their presence in or absence from SVI. Kabat showed that related oligosaccharides are usually better inhibitors than monosaccharides. Thus, the phosphate-free tetrasaccharide repeating unit of SVI is a more efficient inhibitor than ribitol, ribitol 1-phosphate, or any... 

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