Tetraphenylporphyrin TPP Analogues

Among synthetic porphyrins, weso-5,10,15,20-tetraarylpor-phyrins [e.g., H2 (TPP) 9] are the most readily available. The tumor-localizing properties of tetiasulfonated meso- 

In order to investigate the effect of the position of hydroxyl groups on biological activity, Bonnett synthesized 

Czuchajowski and Lozynski showed that replacement of phenyl groups in H2(TPP) with para-cyclophanyl substituents 14 causes bathochromic shifts of all the absorption bands (X,max 417, 514, 549 and 645nm). ° However, these compounds were found to be inactive in vivo. i 

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