Tetranucleotide hypothesis

Part of Chargaffs intent was to disprove the tetranucleotide hypothesis this was the idea that DNA was a monotonous tetranucleotide polymer (AGCT)re and therefore not capable of containing sequence information. Although the data presented above show that DNA cannot be simply a tetranucleotide—if so, all samples would have molar ratios of 0.25 for each base—it was still possible that the DNA from different organisms was a slightly more complex, but still monotonous, repeating sequence. 

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