Tetrahydrofuran, Staudinger reaction

An efficient and operationally simple synthesis of tetrahydrofuran-derived spiro-P-lactams 15 and 16 using the Staudinger reaction of unsymmetrical cyclic ketones has been described <02JCS(P1)571 02SL69>. Similarly, spiro-P-lactams 17 were synthesized via Staudinger reaction of imines derived from 7-oxanorbomenone with alkoxyacetyl chlorides <02TL6405>. 

An efficient synthesis of tetrahydrofuran-derived spiro-p-lactams has been reported to be performed by a Staudinger-type reaction of either 2- or 3-tetra-hydrofuroyl chloride with imines [66]. The reaction was carried out by adding Et3N... 

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