Tetrahydrocephalostatin Fuchs synthesis

On the synthetic front, the discovery of these alkaloids has sparked interest in the construction of unsymmetrical pyrazines, and the methods developed will be useful in other settings as well. The Fuchs group has successfully accomplished landmark syntheses of tetrahydrocephalostatin 12, cephalostatin 7, cephalostatin 12, and ritterazine K and is clearly close to a synthesis of dihydrocephalostatin 1. These efforts have added significantly to the areas of steroid and spiroketal chemistry. 

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