Tetrahydrocannabinol in blood

Cannabis provides a similar example. The detection of A -tetrahydrocannabinol in blood indicates very recent use of the drug (within 8 hours). Further, the concentrations of ll-nor-A -tetrahydrocannabinol-9-carboxylic acid and its glucuronide increase with time, the ratio of the acid to A -tetrahydrocanna-binol increasing to over 50 after about 3 hours. Concentration ratios of drug metabolite or metabolite metabolite of the above type often provide better estimates of the time since ingestion than the individual blood concentrations, especially when the time involved is relatively long. Unless a drug is very rapidly metabolised (as is the case... 

Owens SM, McBay AJ, Reisner HM, Perez-Reyes M (1981) 125 1 radioimmunoassay of delta-9-tetrahydrocannabinol in blood and plasma with a solid-phase second-antibody separation method. Clin Chem 27 619-624... 

B., Leander, K., Lindgren, J. E., Nilsson, I., and Asberg, M. Determination of Tetrahydrocannabinol in Blood Plasma of Cannabis Smokers Mass Spectrom. Biochem. Med., Symp. 1973 361-363 (Pub. 1974) CA 82 773x... 

Determination of A -Tetrahydrocannabinol in Blood by Electron Capture Gas Chromatography Anal. Chem. 45(14) 2331-2335 (1973) ... 

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See also in sourсe #XX -- [ ]

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