Tetrahydro-furan calculation

Zuberbiihler etal. reported stopped-flow kinetic investigations of the oxygenation reactions of a series of tefradentate copper(I) complexes in propionitrile, tetrahydro-furan, and acetone. The formation of [(L °)Cu (02 )]+ can only be followed below 203 K because at a higher temperature it occurs faster than the stopped-flow instrumental limit. On the basis of experimental results, the authors proposed a reaction mechanism, which involved four steps, at least three intermediates. On the basis of the kinetics analysis, spectra for species (intermediates and product) could be calculated. 

Problem 3.21 Calculate the composition of a blend of n-hexane, 1-heptane, and dioctyl phthalate that would have the same solvent properties as tetrahydro-furan. (Take appropriate data from Table 3.5.)... 

Problem 8.4 In an experiment (Szwarc et al., 1956), styrene (9.2 g) was added to 60 mL of tetrahydro-furan containing 3.3x10 mol of sodium naphthalene. Polymerization was carried out at -80°C and after completion (as determined by constant viscosity) an additional 7.7 g of styrene in 50 mL of tetrahydrofuran was added. The nal yield was 16.6 g of polystyrene, i.e., about 100% conversion. Calculate the average molecular weight of the nal polymer. 

The degree of swelling of a corsslinked polymer was determined in different solvents at 30°. Samples were cut into the desired shape and were immersed in large excesses of various solvents, viz hexane, ethyl acetate, chloroform, methyl ethyl ketone, tetrahydro-furan, acetone, dioxane and acetonitrile. The crosslinked polymer was taken out of the solvent after 24 hours. Solvent on the surface was wiped out with a filter paper and then the polymer sample was weighed in a stoppered bottle. Weight of the sample was recorded at 15, 30,4 5, 60, and 90 seconds, after the removal of the sample from the solvent. The swollen weight was determined by linear extrapolation to zero time. The sample was vacuum dried to constant weight. The volume fraction of the polymer in the gel swollen to equilibrium was calculated by ... 

It is clear that, due to the above described characteristics of TS, it would not be possible to design a stable molecule that mimics the TS precisely. However, even cmde TS analogues consisting of relevant features are expected to be excellent reversible inhibitors. To achieve this, the TS analogue should contain the main stmctural features of the TS from both the acceptor and donor. Recently, based on the calculated information, a new scaffold for TS analogues has been designed [445], with an attempt to mimic stmctural features around the reaction centre. The proposed stmctural mimic of TS is represented by the (tetrahydro-2-(methylthio)furan-2-yl)methyl phosphate dianion (1) shown inO Fig. 17. 

Norcantharidin 47 Maleic anhydride (2 g) is suspended in ether and treated with the calculated amount of furan. Reaction occurs gradually with slight evolution of heat. After several hours, cooling the mixture causes separation of the adduct, cw-l,2,3,6-tetrahydro-... 

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