Tetracycline with digoxin

There is an increased risk of toxicity of MTX when administered with the NSAIDs, salicylates, oral antidiabetic drugs, phenytoin, tetracycline, and probenecid. There is an additive bone marrow depressant effect when administered with other drug known to depress the bone marrow or with radiation therapy. There is an increased risk for nephrotoxicity when MTX is administered with other drug that cause nephrotoxicity. When penicillamine is administered with digoxin, decreased blood levels of digoxin may occur. There is a decreased absorption of penicillamine when the dmg is administered with food, iron preparations, and antacids. 

Side effects include dry mouth, constipation, nausea, vomiting, rash, pruritus, dizziness. It adsorbs and interferes with absorption of tetracycline, cimetidine, digoxin and phenytoin. 

The bile acids sequestrants, particularly cholestyramine, can decrease tlie absorption of numerous dru. For tliis reason, tlie bile acid sequestrants should be administered alone and otlier dru given at least 1 hour before or 4 hours after administration of the bile acid sequestrants. There is an increased risk of bleeding when tlie bile acid sequestrants are administered with oral anticoagulants. The dosage of the antico ulant is usually decreased. The bile acid sequestrants may bind with digoxin, tliiazide diuretics, penicillin, propranolol, tetracyclines, folic acid, and tlie thyroid hormone, resulting in decreased effects of th e dru. ... 

The following drugp have a decreased pharmacologic effect when administered with an antacid corticosteroids, digoxin, chlorpromazine, oral iron products, isoniazid, phenothiazines, ranitidine, phenytoin, valproic acid, and the tetracyclines. 

Absorption of certain drugs, including those with neutral or cationic charge as well as anions, may be impaired by the resins. These include digitalis glycosides, thiazides, warfarin, tetracycline, thyroxine, iron salts, pravastatin, fluvastatin, folic acid, phenylbutazone, aspirin, and ascorbic acid. Any additional medication (except niacin) should be given 1 hour before or at least 2 hours after the resin to ensure adequate absorption. Colesevelam does not bind digoxin, warfarin, or reductase inhibitors. 

Tetracycline Tetracycline injections have an acid pH. Incompatibility may reasonably be expected with alkaline preparations or with drugs unstable at low pH. Care should be taken when administering tetracyclines, since chelation takes place with metal ions. Tetracyclines interact with inorganic metal ions. They should not be used with drugs that cause hepatotoxicity and nephrotoxicity (e.g., digoxin, theophylline, ergot alkaloids, methotrexate, oral contraceptives, and penicillins). 

Clinically important, potentially hazardous interactions with acetaminophen, acitretin, aspirin, chloroquine, digoxin, doxepin, fat-soluble vitamins A, D, E, K, hydroxychloroquine, isotretinoin, lovastatin, mycophenolate, raloxifene, sulfasalazine, sulfonylureas, tetracycline, tricyclic antidepressants, ursodeoxycholic acid, valproic acid... 

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