2.3.7.8- Tetrachlorodibenzo-p-dioxm

Tetrachlorodibenzo-p-dioxm Thymus atrophy (rat, mouse, guinea pig)... 

Walker, M.K., Spitsbergen, J.M., Olson, J.R., Peterson, R.E. (1991) 2,3,7,8-tetrachlorodibenzo-p-dioxm (TCDD) toxicity during early life stage development of lake trout (salvelinus namaycush). Can. J. Fish Aquatic Sci. 48, 875-883. 

Bagchi, D. et al., Time-dependent effects of 2,3,7,8-tetrachlorodibenzo-p-dioxm on serum and urine levels of malondialdehyde, formaldehyde, acetaldehyde and acetone in rats, Toxicol Appl Pharmacol, 123, 83, 1993. 

Tetrachlorodibenzo- -dioxm- C, U.L. 2,7-Dichlorodibenzo-p-dioxin- C, U.L. (0.500 gram) was stirred with 10 ml of chloroform containing trace amounts of FeCls and L and heated to reflux temperature while chlorine gas was passed into the mixture for 18 hours. After cooling, the white insoluble product was collected by filtration and triturated with 15 ml of boiling chloroform. The insoluble portion was transferred to a sublimation flask where it was vacuum-sublimed at 140 °C. The sublimate was recrystallized from 2.5 ml of anisole and washed with chloroform. The product weighed 0.229 gram and contained 2.9 /xCi of radioactivity per mg. 

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