Tests Employed to Acquire Information on Stereomutation

FIGURE 4.8 Racemization tests employed for acquiring information on stereomutation. Couplings are carried out, and the isomeric content of the products is determined by a variety of techniques. AAA = amino acid analyzer GLC = gas-liquid chromatography. 

W Anderson, RW Young. Use of diester chlorophosphites in peptide synthesis. J Am Chem Soc 74, 5307, 1952. 

MW Williams, GT Young. Amino-acids and peptides. Part XVI. Further studies of racemisation during peptide synthesis. J Chem Soc 881, 1963. 

F Weygand, A Prox, L Schmidhammer, W Konig. Gas chromatographic investigation of racemization in peptide synthesis. Angew Chem 75, 282, 1963. 

M Bodanszky, LE Conklin. A simple method for the study of racemization in peptide synthesis. Chem Commun 773, 1967. 

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