Ternary systems weak binding

The VO(ma)2 l-methylimidazole (1-ImMe) system was found to be a good speetroseopie model of the protein adduct formed between VO(ma)2 and HSA. Simulation of the EPR spectra of all solution components (VO(ma)2, VO(ma)2(l-ImMe), VO(HSA)strong, VO(HSA) eok, VO(ma)2(HSA), and VO(maXHSA)) demonstrated the uniqueness of the spin Hamiltonian parameters for both the adduet and ternary complex relative to VO(ma)2, and the close similarity of parameters between the VO(ma)2(l-ImMe) and VO(ma)2(HSA) adducts. Thus, VO(ma)2 was proposed to form a 1 1 adduct complex with HSA most likely through the H3 imidazole [31] binding to an equatorial position of cA-VO(ma)2 through displacement of the weakly bound water [80],... 

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