Template directed ligation polymerization

Since it has not been possible to cover all the valuable contributions that have been made in these fields of study, we have instead organized the discussion around a minimal scheme for template directed ligation. This minimal scheme will be compared with the autonomous natural genomes that self-replicate via template directed polymerization reactions. The advantages and limitations of each step in the minimal scheme are discussed with respect to the structural diversity in the template that will make it possible to extend these reactions to new materials and new polymerization strategies. 

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